FILE: /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php LINE: 56
公开
法律状态公告日：2018-11-13
法律状态：公开
描述信息：公开
相关专利推荐
| 名称： | 一种高亲和PD-1蛋白突变体 |
|---|---|
| 申请号： | CN201810543576 |
| 申请日期： | 2018-05-31 |
| 申请人： | 郑州大学 |
| 发明人： | 杜江峰; 高艳锋; 吴亚红; 赵文珊; 祁元明 |
| 地址： | 450000 河南省郑州市高新技术开发区科学大道100号 |
| 主分类号： | C07K14/705 |
| 分类号： | C07K14/705; C12N15/12; A61K38/17; A61P35/00 |
| 主权项： | |
| 摘要： | 本发明公开了一种高亲和PD‑1蛋白突变体，通过将野生型PD‑1的四个氨基酸位点突变：M70I、S87W、A129H、K135M；得到具有更高亲和力的PD‑1蛋白突变体，不但可以显著上调T细胞活化和细胞因子分泌，同时还可以降低使用剂量，降低治疗成本。本发明还提供了该突变体或其制剂在制备治疗、预防、或者缓解肿瘤相关疾病等药物中的用途。 |
| start date | end date | title | description | icon | date limit | importance | link | modal |
|---|---|---|---|---|---|---|---|---|
| 2018-11-13 | 公开 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
| 2018-12-28 | 实质审查的生效 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 |
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错误位置
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#1 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->theme_bar('get_bar_id', Array)
#2 [internal function]: Home\Controller\PraiseController->get_bar_id_by_from_id()
#3 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(173): ReflectionMethod->invoke(Object(Home\Controller\PraiseController))
#4 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(110): Think\App::invokeAction(Object(Home\Controller\PraiseController), 'get_bar_id_by_f...')
#5 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(204): Think\App::exec()
#6 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/Think.class.php(120): Think\App::run()
#7 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/ThinkPHP.php(97): Think\Think::start()
#8 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/index.php(27): require('/home/ftp/1520/...')
#9 {main}
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