FILE: /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php LINE: 56
申 请 号:CN201810249347
专利名称:稳定和可溶的抗体
专利权人:艾斯巴技术 诺华有限责任公司
交易方式:协议
参考价格: 面议
加入对比
索取出让意向书
名称: | 稳定和可溶的抗体 |
---|---|
申请号: | CN201810249347 |
申请日期: | 2011-10-24 |
申请人: | 艾斯巴技术 诺华有限责任公司 |
发明人: | L·博拉斯; D·尤里奇 |
地址: | 瑞士施利伦 |
主分类号: | C07K16/24 |
分类号: | C07K16/24; C12N15/13; A61K39/395; A61P27/02; A61P27/06 |
主权项: | US61405798 20101022; US61484749 20110511 |
摘要: | 本发明提供了经修饰以减少聚集倾向的抗体,以及产生此类抗体的方法。本发明还提供了特异于TNF的特别稳定的可溶性scFv抗体和Fab片段,其包含就稳定性、溶解度、TNF的体外和体内结合以及低免疫原性进行优化的特定轻链和重链序列。还公开了用于表达本发明的重组抗体的核酸、载体和宿主细胞、用于分离其的方法以及所述抗体在医药中的用途。 |
start date | end date | title | description | icon | date limit | importance | link | modal |
---|---|---|---|---|---|---|---|---|
2018-08-03 | 公开 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2018-08-28 | 实质审查的生效 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 |
:( FILE: /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php LINE: 56 #0 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->__call('theme_bar', Array) ThinkPHP3.2.3 { Fast & Simple OOP PHP Framework } -- [ WE CAN DO IT JUST THINK ]curl exec failed 'Couldn't connect to server'
错误位置
TRACE
#1 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->theme_bar('get_bar_id', Array)
#2 [internal function]: Home\Controller\PraiseController->get_bar_id_by_from_id()
#3 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(173): ReflectionMethod->invoke(Object(Home\Controller\PraiseController))
#4 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(110): Think\App::invokeAction(Object(Home\Controller\PraiseController), 'get_bar_id_by_f...')
#5 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(204): Think\App::exec()
#6 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/Think.class.php(120): Think\App::run()
#7 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/ThinkPHP.php(97): Think\Think::start()
#8 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/index.php(27): require('/home/ftp/1520/...')
#9 {main}