FILE: /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php LINE: 56
名称: | GARP-TGF-β抗体 |
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申请号: | CN201880046262 |
申请日期: | 2018-05-11 |
申请人: | |
发明人: | S.范德沃宁; F.博吉翁斯; T.德雷尔; L.马里恩; G.德伯克; S.利纳特; S.卢卡斯; P.库利 |
地址: | 比利时根特 |
主分类号: | C07K16/28 |
分类号: | C07K16/28; A61K39/395; A61K39/00 |
主权项: | 1.抗体或其抗原结合片段,其结合人GARP和TGF-β1的复合物,其中所述抗体或其抗原结合片段包含重链可变结构域(VH),其中: VH CDR3包含氨基酸序列YEWETVVVGDLMYEYEY (SEQ ID NO : 13),VH CDR2包含氨基酸序列RIDPEDAGTKYAQKFQG (SEQ ID NO : 12),且VH CDR1包含氨基酸序列SYYID (SEQ ID NO : 4)。 |
摘要: | 本发明涉及结合GARP和TGF‑β1的复合物、尤其是人GARP和人TGF‑β1的复合物的抗体及其抗原结合片段。这些抗体和抗原结合片段表现出有利特性的组合,包括高亲和力抗原结合和抑制活性TGF‑β从调节性T细胞释放的能力。本发明的抗体和抗原结合片段对脱酰胺、异构化和氧化是相对抗性的,使得它们表现出改善的稳定性。 |
start date | end date | title | description | icon | date limit | importance | link | modal |
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2020-03-31 | 公开 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 |
:( FILE: /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php LINE: 56 #0 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->__call('theme_bar', Array) ThinkPHP3.2.3 { Fast & Simple OOP PHP Framework } -- [ WE CAN DO IT JUST THINK ]curl exec failed 'Timeout was reached'
错误位置
TRACE
#1 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->theme_bar('get_bar_id', Array)
#2 [internal function]: Home\Controller\PraiseController->get_bar_id_by_from_id()
#3 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(173): ReflectionMethod->invoke(Object(Home\Controller\PraiseController))
#4 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(110): Think\App::invokeAction(Object(Home\Controller\PraiseController), 'get_bar_id_by_f...')
#5 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(204): Think\App::exec()
#6 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/Think.class.php(120): Think\App::run()
#7 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/ThinkPHP.php(97): Think\Think::start()
#8 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/index.php(27): require('/home/ftp/1520/...')
#9 {main}