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申 请 号:CN201280072668
专利名称:抗人死亡受体5胞外区的人源化单克隆抗体
专利权人:和元生物技术(上海)股份有限公司
交易方式:协议
参考价格: 面议
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名称: | 抗人死亡受体5胞外区的人源化单克隆抗体 |
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申请号: | CN201280072668 |
申请日期: | 2012-10-26 |
申请人: | 和元生物技术(上海)股份有限公司 |
发明人: | 郑德先; 邱宇鹤; 刘彦信 |
地址: | 201203 上海市中国(上海)自由贸易试验区蔡伦路781号406室 |
主分类号: | C07K16/30 |
分类号: | C07K16/30; C12N15/13; C12N15/79; C12N5/28; A61K39/00; A61P35/00 |
主权项: | 一种抗人死亡受体5胞外区的人源 |
摘要: | 本发明提供了抗人死亡受体5(DR5)胞外区的人源化单克隆抗体,其包括与SEQ?ID?NO:1所示的氨基酸序列同一性至少为90%的轻链可变区氨基酸序列,与SEQ?ID?NO:2所示的氨基酸序列同一性至少为90%的重链可变区氨基酸序列,以及人抗体功能IgG1的恒定区。本发明还提供了所属人源化单克隆抗体的编码核苷酸序列,重组真核表达载体,以及所述抗体的生产方法,其组合物以及用途。本发明所述的人源化单克隆抗体在体内外对多种肿瘤细胞具有特异性的凋亡诱导活性,可单独或与DR5的天然配体肿瘤坏死因子相关凋亡诱导配体或其它药物联合使用,用于多种肿瘤和与DR5高表达相关的疾病的治疗。 |
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2014-12-24 | 公开 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2015-01-14 | 实质审查的生效 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2016-03-09 | 专利申请权、专利权的转移 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2016-03-09 | 著录事项变更 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2016-12-21 | 授权 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 |
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#1 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->theme_bar('get_bar_id', Array)
#2 [internal function]: Home\Controller\PraiseController->get_bar_id_by_from_id()
#3 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(173): ReflectionMethod->invoke(Object(Home\Controller\PraiseController))
#4 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(110): Think\App::invokeAction(Object(Home\Controller\PraiseController), 'get_bar_id_by_f...')
#5 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(204): Think\App::exec()
#6 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/Think.class.php(120): Think\App::run()
#7 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/ThinkPHP.php(97): Think\Think::start()
#8 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/index.php(27): require('/home/ftp/1520/...')
#9 {main}