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申 请 号:CN201810175220
专利名称:抗CD3的纳米抗体CD3/Nb14及其制备方法与应用
专利权人:广西医科大学
交易方式:协议
参考价格: 面议
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名称: | 抗CD3的纳米抗体CD3/Nb14及其制备方法与应用 |
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申请号: | CN201810175220 |
申请日期: | 2018-03-02 |
申请人: | 广西医科大学 |
发明人: | 卢小玲; 杨晓梅; 段斯亮 |
地址: | 530021 广西壮族自治区南宁市双拥路22号 |
主分类号: | C07K16/28 |
分类号: | C07K16/28; C12N15/13; C12N5/10; A61K39/395; A61P35/00 |
主权项: | 1.纳米抗体,包含决定簇互补区;其特征在于: 所述纳米抗体的决定簇互补区由CDR1、CDR2和CDR3组成; 所述CDR1的氨基酸序列为序列表中SEQ ID No.8的第23-32位氨基酸; 所述CDR2的氨基酸序列为序列表中SEQ ID No.8的第49-55位氨基酸; 所述CDR3的氨基酸序列为序列表中SEQ ID No.8的第93-113位氨基酸。 |
摘要: | 本发明公开了抗CD3的纳米抗体CD3/Nb14及其制备方法与应用。本发明所提供的纳米抗体,包含决定簇互补区和框架区;所述纳米抗体的决定簇互补区由CDR1、CDR2和CDR3组成;通过本发明所公布的纳米抗体核苷酸序列及宿主细胞,该纳米抗体能够在大肠杆菌内高效表达,应用于CD3分子检测试剂的研发,制备肿瘤抑制剂或肿瘤细胞抑制剂以及制备抑制CD3活性和促进T细胞增殖的药物。 |
start date | end date | title | description | icon | date limit | importance | link | modal |
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2019-09-10 | 公开 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2019-10-08 | 实质审查的生效 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 |
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#1 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->theme_bar('get_bar_id', Array)
#2 [internal function]: Home\Controller\PraiseController->get_bar_id_by_from_id()
#3 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(173): ReflectionMethod->invoke(Object(Home\Controller\PraiseController))
#4 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(110): Think\App::invokeAction(Object(Home\Controller\PraiseController), 'get_bar_id_by_f...')
#5 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(204): Think\App::exec()
#6 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/Think.class.php(120): Think\App::run()
#7 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/ThinkPHP.php(97): Think\Think::start()
#8 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/index.php(27): require('/home/ftp/1520/...')
#9 {main}