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申 请 号:CN201810632019
专利名称:一种用于预防犬弓形虫感染的疫苗及其制备方法
专利权人:侯峰
交易方式:协议
参考价格: 面议
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名称: | 一种用于预防犬弓形虫感染的疫苗及其制备方法 |
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申请号: | CN201810632019 |
申请日期: | 2018-06-19 |
申请人: | 侯峰 |
发明人: | 侯峰; 曹利利; 宫鹏涛; 李思明; 陈星远; 丁鹤; 王典 |
地址: | 300457 天津市滨海新区宏达街19号 |
主分类号: | C07K14/45 |
分类号: | C07K14/45; C12N15/30; C12N15/70; C12N1/21; A61K39/002; A61P33/02; C12R1/19 |
主权项: | |
摘要: | 发明提供一种具有弓形虫免疫原性的蛋白,该蛋白为cyclophilin突变体蛋白,由SEQ ID 2所述氨基酸序列组成。本发明还提供一种可编码具有弓形虫免疫原性的蛋白的核酸,具有SEQ ID 1所述的核酸序列。本发明提供一种疫苗,其中疫苗是将弓形虫抗原基因双酶切后连接pET28a等原核表达载体,转化入BL21(DE3)等原核表达工程菌,诱导其高效表达,纯化后得到的蛋白为可溶性蛋白,并且保持其特有的免疫原性。本发明对cyclophilin蛋白的序列进行优化,使其在原核细胞大肠杆菌中的表达量显著增加。本发明提供的疫苗可以在工程菌种制备,再添加疫苗佐剂,制备而成,其疫苗保持其特有的免疫原性,适合于工业化生产。 |
start date | end date | title | description | icon | date limit | importance | link | modal |
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2018-11-16 | 公开 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 | |||||
2018-12-11 | 实质审查的生效 | js/timeglider/js/timeglider/icons/verticalLineGray.png | 50 |
:( FILE: /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php LINE: 56 #0 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->__call('theme_bar', Array) ThinkPHP3.2.3 { Fast & Simple OOP PHP Framework } -- [ WE CAN DO IT JUST THINK ]curl exec failed 'Couldn't connect to server'
错误位置
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#1 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/Application/Home/Controller/PraiseController.class.php(56): Yar_Client->theme_bar('get_bar_id', Array)
#2 [internal function]: Home\Controller\PraiseController->get_bar_id_by_from_id()
#3 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(173): ReflectionMethod->invoke(Object(Home\Controller\PraiseController))
#4 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(110): Think\App::invokeAction(Object(Home\Controller\PraiseController), 'get_bar_id_by_f...')
#5 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/App.class.php(204): Think\App::exec()
#6 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/Library/Think/Think.class.php(120): Think\App::run()
#7 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/ThinkPHP/ThinkPHP.php(97): Think\Think::start()
#8 /home/ftp/1520/ipa361_com-20150420-MrH/ipa361.com/mapi/index.php(27): require('/home/ftp/1520/...')
#9 {main}